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Probiotic News
 

The following are current news stories picked up from various feeds about the latest probiotic news and events that are shaping and changing what we know about the science behind probiotics.

Researchers unveil complete genetic make-up of cavity-causing bacterium
December 24th, 2009

Researchers have uncovered the complete genetic make-up of the cavity-causing bacterium Bifidobacterium dentium Bd1, revealing the genetic adaptations that allow this microorganism to live and cause decay in the human oral cavity. The study, led by Marco Ventura's Probiogenomics laboratory at the University of Parma, and Prof. Douwe van Sinderen and Dr Paul O'Toole of the Alimentary Pharmabiotic Centre at University College Cork, is published December 24 in the open-access journal PLoS Genetics.

Bifidobacteria, largely known as long-term beneficial gut bacteria, are often included as probiotic components of food to aid digestion and boost the immune system. However, not all species within the genus Bifidobacterium provide beneficial effects to the host's health. In fact, the Bifidobacterium dentium species is an opportunistic pathogen since it has been linked to the development of tooth decay. The genome sequence of B. dentium Bd1 reveals how this microorganism has adapted to the oral environment through specialized nutrient acquisition features, acid tolerance, defences against antimicrobial substances and other gene products that increase fitness and competitiveness within the oral niche.

This report identifies, through various genomic approaches, specific adaptations of a Bifidobacterium taxon to a lifestyle as a tooth decay-causing bacterium. The data in this study indicate that the genome of this opportunistic pathogen has evolved through only a small number of horizontal gene acquisition events, highlighting the narrow boundary that separates bacteria that are long-term residents on or in the human body from opportunistic pathogens.

Source: Public Library of Science

Got Gas? Probiotics Can Make It a Problem of the Past

New Clinical Study Shows Probiotic Strain -- BACILLUS Coagulans -- Reduces Intestinal Gas Symptoms in Healthy Adults and Improves Quality of Life Even for Those Without Specific Gastrointestinal (GI) Disorders

CLEVELAND, OH--(Marketwire - December 15, 2009) - A clinical study just published in BMC Gastroenterology found that an over-the-counter product containing the probiotic strain, Bacillus coagulans GBI-30, PTA-6086, trademarked by Ganeden Biotech as GanedenBC30, was significantly more effective than placebo in providing relief to subjects suffering from intestinal gas. Bacillus coagulans has already been shown to be effective in more serious disorders, such as irritable bowel syndrome (IBS), but the study is the first to show a gastrointestinal (GI) benefit in otherwise healthy adults.

The study adds to the growing body of evidence behind the Bacillus coagulans strain, which is rapidly gaining popularity in fortified foods and beverages and provides additional rationale for why the general population should consider taking probiotics everyday. Today, nearly half of all Americans report that uncomfortable digestive problems affect their day-to-day lives, according to a survey by the Foundation for Digestive Health and Nutrition.

The randomized, double-blind, placebo-controlled study found that subjects taking Digestive Advantage Gas Defense Formula, an over-the-counter product marketed by Ganeden Biotech that contains the Bacillus coagulans probiotic strain, experienced statistically significant improvement versus placebo in the Gastrointestinal Symptom Rating Scale (GSRS) total score over the four weeks of product use. While there are several over-the-counter products marketed for intestinal gas, few have clinical evidence to support their effectiveness.

The authors of the study concluded that Digestive Advantage Gas Defense Formula was effective in improving the quality of life and reducing GI symptoms in adults with intestinal gas symptoms and no GI diagnoses.

"Many people may not understand that probiotics are more than something you find just in yogurt," said Dr. Michael Roizen, New York Times best-selling author, co-founder of RealAge, and Chief Wellness Officer at the Cleveland Clinic. "Taking probiotics is a good habit that can really benefit your digestive system, which is intricately connected to your overall health, yet most Americans are still unfamiliar with them and the good they can do."

Intestinal gas results from the fermentation of undigested carbohydrates in the lower bowel. The lack of appropriate enzymes to break down these carbohydrates before they reach the lower bowel is a major factor, as is the case with people who are lactose intolerant. Bacillus coagulans has been shown in an in vitro model of the human digestive tract to aid in the digestion of carbohydrates, including lactose and fructose. Because Bacillus coagulans can grow for days throughout the intestinal tract, it can help break down carbohydrates before they cause gas.

"We were impressed by the results given the strong placebo effect present in this study, a phenomenon quite common in studies involving subjective measures," said Douglas Kalman, Ph.D., R.D., author of the 61 subject study and fellow of the American College of Nutrition. "Although Bacillus coagulans has previously been shown to be effective for serious GI disorders, such as IBS and antibiotic associated diarrhea, this study suggests that the general population can also benefit and address a common GI complaint."

David Keller, M.D., who oversees scientific affairs at Ganeden, said, "Digestive Advantage Gas Defense Formula is unique among today's products designed to alleviate gas because you don't have to take it with every meal. Consumers find many other gas products less effective and less convenient -- as they are recommended to be consumed at the time you're eating gas-causing food or after gas is already an issue. Consumers don't always know which foods are going to cause gas, and they don't want to wait until they have gas to do something about it."

Marshall Fong, Ganeden's vice president of marketing, said, "Consumers who try Digestive Advantage are much more likely to become repeat purchasers than people who try 30 other of the most popular brands of digestive products sold in store, according to a nationally-representative sample of 70,000 households. We believe people are more loyal consumers of our products because they really work, and the clinical study supports that."

Several food and beverage companies have recently added Ganeden's probiotic strain to their products. Ganeden Biotech provided a research grant to help fund study highlighted in this news release, and the company intends to continue supporting research to show how its probiotic strain can benefit both the general population and those with specific health issues, added Fong.

For complete study findings, please visit http://www.biomedcentral.com/1471-230X/9/85.

 

Danisco technology toughens up probiotic cultures
September 15th, 2009

Patent-pending encapsulation technique promises significantly improved probiotic stability

Danisco Bio Actives has today unveiled outstanding initial results using novel encapsulation technology to improve the survival of probiotic cultures at high temperatures and during storage in semi-moist applications.

Trials with an encapsulated Lactobacillus acidophilus culture have found that resistance to temperatures up to 50°C (122°F) increased ten-fold when heat treatment was applied for 24 hours under dry conditions. In addition, the probiotic strain retained 60% viability after five months’ storage at room temperature in a nutritional bar with a moisture level of 0.35Aw.

Additional tests with the encapsulated probiotic in a recombined cheese application showed processing resistance 2,500 times superior to that of the control.

New probiotic potential
Isabelle Mazeaud, Bioprocess Development Senior Scientist at Danisco, presented the technology at the Industrial Workshop on Microencapsulation of Flavors and Bioactives in Minnesota, USA.

A high level of probiotic survival all through process and storage is both technically and economically critical for food and supplement manufacturers,’ she comments. ’The new encapsulation technique will eventually open up new development possibilities in nutrition bars, infant formulas, breakfast cereals, powder beverages and processed cheese.’

Free of solvents and comprising food-grade, water-soluble components, the patent-pending technology meets the requirements of the industry and further tests are still running to ensure the presence of live active bacteria throughout the desired shelf life of various food and nutritional products.

Proactive bioprocess development
Following the recent opening of its Bioprocess Development Centre in Dangé, France, Danisco Bio Actives continues to consolidate its expertise in processing sensitive microorganisms, such as cultures.

’Danisco has always been proactive in searching for innovative technologies to improve the processing of cultures and deliver the potency and function that food and supplement manufacturers require,’ said Egon Bech Hansen, Vice President R&D for Danisco Bio Actives.

The company already offers a range of probiotic cultures with superior stability exceeding 24-month shelf life at room temperature in very low moisture applications.
 

Ganeden Biotech takes next step: Probiotics for livestock feed

June 23, 2009

MAYFIELD HEIGHTS, Ohio — Ganeden Biotech Inc. has taken another step in its mission to get Americans to eat healthy by launching its patented probiotic as an additive for livestock feed.

Founded in 1997, Ganeden has been packaging its “good bacteria” in the form of dietary supplement capsules for more than a decade.

Probiotics are live microorganisms containing bacteria or yeasts that can make people who take them healthier. Some believers say probiotics improve their digestion, boost their immunity and even enable them to digest dairy foods.

Last year, Ganeden began selling its probiotic – particularly hearty strains of  Bacillus coagulans – as a food ingredient for humans. GanedenBC30 is added to foods from yogurt to energy bars to ice cream.

Now, the company is repackaging its bacteria yet again and selling it as ProGan, an additive for livestock feed. The thinking is the probiotic will promote health and digestion of livestock so that farmers won’t use antibiotics or other synthetic substances to keep their animals healthy.

Antibiotics are fed to some livestock to keep them healthy and promote growth. However, some scientists say that eating food like pork from animals that were fed antibiotics is destroying the effectiveness of the bacteria-fighting medicines as well as polluting the environment.

Ganeden has established recommended ProGan feeding rates for cattle (36 grams per day), pigs (5.5 grams per day) and chickens (1 gram per day). The product, which comes in pellet form, is sold directly by Ganeden in 50-pound bags or in bulk quantities.

“We’re excited to enter the farming and livestock production industry with ProGan,” said Andy Lefkowitz, Ganeden’s chief executive, in a written statement. “This innovative product provides farmers and ranchers with a natural and effective way to improve livestock health and positively influence feed conversion without the use of antibiotics.”

July 22, 2009 - Wednesday 

Red Mango Introduces the First Probiotic Iced Tea July 27

          Red Mango introduces first probiotic iced teas July 27. The delicious and nutritious teas are available in three unique flavors.

DALLAS, TX UNITED STATES
 
Includes New and Exclusive Probiotic GanedenBC30(R), in Its All Natural Frozen Yogurt
DALLAS, July 22 /PRNewswire/ -- Red Mango, the fastest-growing retailer of authentic nonfat frozen yogurt, today announced it will become the first retailer to offer made-to-order iced teas fortified with probiotics. Three proprietary flavors, all incorporating GanedenBC30(R), a patented strain of probiotic shown to help support the immune system and regulate the digestive system, are available in participating Red Mango stores beginning July 27. Additionally, Red Mango's Original, Pomegranate by POM Wonderful(R) and Tangomonium(TM) authentic frozen yogurt sold throughout New York will now include GanedenBC30 through an exclusive agreement. By September, all other Red Mango stores will have frozen yogurt with GanedenBC30.

Lemonocity(TM) (Lemonade Green Tea), Mysteaque(TM) (Vanilla Black Tea) and Fanteasia(TM) (Wildberry Hibiscus Tea) iced teas are each uniquely delicious, low-calorie, sweetened with natural cane sugar and contain a significant amount of probiotics, or good bacteria. Since its inception, Red Mango has focused on educating its customers about the advantages of authentic frozen yogurt and the probiotics Red Mango contains.

"Red Mango provides easy and delicious ways to be healthy," said Dan Kim, Red Mango's founder, president and chief executive officer. "Our new iced teas have both the benefits of antioxidants and probiotics, and our frozen yogurt became even healthier with the addition of GanedenBC30."

GanedenBC30 provides additional health benefits because of its excellent stability, which helps it survive better through the digestive system. Scientists now recognize that 70 percent of our immune system is actually living in the digestive tract, which emphasizes the importance of digestive health.

"Red Mango is redefining a healthy treat. Their nonfat frozen yogurt, already naturally rich in probiotics is now fortified with the GanedenBC30 strain. It's a delicious all-natural treat that is good for you," stated Dr. Steven Pratt, the physician who revolutionized the superfoods movement and author of bestselling "SuperFoodsRx" and the recently published "SuperHealth: 6 Simple Steps, 6 Easy Weeks, 1 Longer, Healthier Life."

Red Mango frozen yogurt is 100 percent natural, made in the ways real yogurt is made, and offers a deliciously authentic yogurt flavor. It contains significant amounts of live and active cultures that are beneficial to one's health, has no fat, is gluten-free and contains no preservatives or artificial ingredients.

In 2007, Red Mango became the first natural frozen yogurt concept in the U.S. to be certified by the National Yogurt Association's Live and Active Culture seal program, which confirms that Red Mango meets or exceeds the criteria for healthy frozen yogurt.
 


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